Scalable Production Technology
in a Compact Benchtop System
The Centramate™ 500 S benchtop tangential flow filtration system provides biotechnology and biopharmaceutical drug developers & manufacturers with an ultra-compact portable unit for process development in ultrafiltration (UF) and microfiltration (MF) applications.Designed for all applications requiring concentration and diafiltration of suspended microparticulates (such as cell suspensions and lysates) or dissolved solutes (such as proteins or nucleic acids), the sanitary, self-venting, fully drainable design meets the demands of cGMP environments, with full traceability of process-wetted materials.Using the Centramate 500 S system for process development, time, risk and process volumes are all minimized.
特点
- Compact Flowpath - the ultra-compact flow path of the Centramate 500 S system allows users to operate at volumes as low as 170mL (when using a single Centramate membrane cassette) enabling high concentration factors and minimizing operating volumes
- Scalable Process Technology - designed through experience, the Centramate 500 S system meets the requirements for cGMP equipment with a comprehensive qualification and documentation package, calibrated process instrumentation and hygienic design
- Direct Flow Measurement - the magnetic inductive flowmeter provides direct flow measurement during operation, making system operation safe, accurate and user- friendly
- High Yield and Product Recovery - the hygienic, completely drainable flow path of the Centramate 500 S system enables high product yield, optimum product recovery and easy cleaning
- Safety in Operation - an adjustable pressure interlock provides product and operator safety in a robust and reliable TFF system
- Pressure Independent Flow - the four-piston diaphragm pump delivers constant flow even as the system pressure increases
- Data Logging Capability - data from the process instrumentation can be exported to a PC or laptop computer via the USB port on the Centramate 500 S system
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文件包
- Calibration certificates for measuring instruments
- Drawings (P&ID, Layout)
- User manual
- Electrical wiring documentation incl. certificates
- Welding documentation incl. certificates
- Supplier literature
- 3.1 certificates for product wetted parts
- FDA conformity (EPDM); CE declaration
- Generic IQ documentation
优势
- The graduated glass vessel provides full visibility and indication of fluid level during operation, so volumes can be closely controlled
- The positive displacement diaphragm pump provides pressure independent flow, ensuring critical parameters do not vary during concentration
- Scalable process technology makes the system ideal for scale-up and scale-down studies
- Direct flow measurement with the magnetic inductive flowmeter means accurate, safe and simple operation
- With an interlock controlling the recirculation pump, operator and product safety is maximized
- To eliminate transcription and recording errors, the Centramate 500 S system has a built in data acquisition system which can be connected to a PC via a USB cable
- The data can be displayed on the screen and exported to the hard drive of a connected computer.The data can be imported easily into Microsoft* Excel*
*Microsoft and Excel are trademarks of Microsoft
Click here to download a brochure for the Centramate 500 S TFF System (PDF, 2.7 Mb)
Operating Conditions
| Pressure Range | 0 to 6 barg (0 to 87 psig) |
| 温度范围 | 0° C to +45° C (32° F to 113° F) |
| 流速 | 15 - 600 L/hr |
Operating Volumes
| Maximum Working Volume¹ | 5 liter (nominal) |
| Minimum Working Volume² | 170 毫升 |
² 170 mL is the minimum working volume when using a single Centramate membrane cassette.Actual minimum working volume will be dependent on the installed membrane area and should be measured
Dimensions and Weight
| 尺寸 | W 480 mm x L 605 mm x H 945 mm (W 19" x L 24" x H 37") |
| 重量 | 50 kg (110 lb) |
Power Requirements
| CM500SE Version | 220 V / 50 Hz |
| CM500SW Version | 110V / 60 Hz |
| 电源 | 370 W |
Component Specifications
| COMPONENT | 机型 | Materials | SURFACE FINISH | CAPACITY/OTHER |
| Cassette Holder | Centramate | 316L Stainless Steel | 0.8 μm Ra, electropolished | 0.1 - 0.5 m² membrane area |
| Tie-rods & Washers | 不可用 | 304 Stainless Steel | 不可用 | 不可用 |
| Nuts | 不可用 | Bronze | 不可用 | 不可用 |
| Vessel | 不可用 | Borosilicate Glass | 不可用 | 5 L |
|
Recirculation Pump |
4 piston diaphragm pump | 316L Stainless Steel | 0.8μm Ra, electropolished | 600 升/小时 |
| Diaphragm | 不可用 | Santoprene* | 不可用 | 不可用 |
| Flowmeter | Magnetic Inductive | 316L Stainless Steel | 0.8μm Ra, electropolished | 600 升/小时 |
| Pressure Indicator | 不可用 | 不可用 | 不可用 | 不可用 |
| Chemical Seal | 不可用 | 316L Stainless Steel | 0.8μm Ra | -1 to +6 bar |
| Transmitter | 2-wire system | 不可用 | 不可用 | 4 - 20 mA |
| Valves | Diaphragm | 316L Stainless Steel | 0.8μm Ra, electropolished | 不可用 |
| Diaphragm | 不可用 | EPDM | 不可用 | 不可用 |
| Piping | Weldron, longitudinal seamed | 316L Stainless Steel | 0.8μm Ra, electropolished | 不可用 |
| Gaskets | ½ inch sanitary | EPDM | 不可用 | 不可用 |
| Vessel Outlet / Inlet Tubing | 不可用 | Silicon | 不可用 | 不可用 |
| Frame | Enclosed square profile | 304 Stainless Steel | 不可用 | 不可用 |
| Cabinet | 不可用 | 304 Stainless Steel | 不可用 | IP54 |
Systems Information
| 描述 | Part Number |
| Centramate 500 S TFF System - 220 V / 50 Hz | CM500SE |
| Centramate 500 S TFF System – 110 V / 60 Hz | CM500SW |
配件
| Vessel | |
| O-ring | CM005OR |
| Vessel lid | CM005LD |
| Vessel lid clamp | CM005LC |
| Support & clamp (including rubber) | CM005GS |
| Vessel inlet /outlet tubing | CM005TU |
| Glass Vessel | CM005GR |
| Components | |
| Pressure Sensor | CM012PS |
| Flow Sensor | CM012FS |
| Drain Valve | CM012DV |
| System Valve | CM012SV |
| Pump - membrane and spare kit | PQ808X01 |
