pall,颇尔,采用 Delta 再生纤维素膜的 T-系列 TFF 膜包,DC010T01, DC010T02, DC010T12, DC010T06, DC010T26, DC030T01, DC030T02, DC030T12, DC030T06, DC030T26

pall,颇尔,采用 Delta 再生纤维素膜的 T-系列 TFF 膜包

Low Protein Binding Delta Membrane Used in the Proven T-Series Cassette Design Optimizes Process Economics

• Improved process performance.Cassettes are designed to provide optimal mass transfer to improve your process economics.
• Increased safety, reliability, and reproducibility.Superior new materials of construction are durable and stable, and exhibit very low extractables.Membrane is backpressure resistant up to 4.1 barg (60 psig).
• Easy scale up for robust purification processes.Available in scalable formats with the same materials of construction from development to production-scale processes.  
• High flux, high selectivity, and low protein binding are achieved through the use of Delta regenerated cellulose membrane.

 

Delta 再生纤维素膜

Delta 再生纤维素膜可提供高流量和选择性。这些专门研发的膜可最大程度地降低表面蛋白质结合以及膜的填隙结构。这类亲水性膜显示了低蛋白质吸附特征，是涉及亲水性蛋白质工艺的理想选择。Delta 再生纤维素膜具有低污垢特征，可保证生产运行中的稳定性能或流量。其易于清洁，仅 0.8N 的盐溶液即可恢复其标准水通量（NWP）。

 

图 1

T-Series Cassettes with Delta Membrane Offer Excellent Scalability Among Formats

T01 93 cm2 (0.1 ft2) EFA	T02 186 cm2 (0.2 ft2) EFA	T12 0.1 m2 (1.1 ft2) EFA	T06 0.5 m2 (5.4 ft2) EFA	T26 2.5 m2 (27 ft2) EFA

 

The T-Series Advantage

Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:

• The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
• Larger feed and permeate ports provide lower pressure drops.
• T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.

To test the new T-Series cassettes with Delta membrane in your process, contact 上海羽令 today.

T-Series cassettes with Delta regenerated cellulose membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes.They are especially useful in:

• Antibody fragments (Fab)
• Purification and recovery of antibodies 
• Concentration and diafiltration of recombinant proteins
• 血浆组分分离和纯化

Product Platforms

T-Series cassettes complement 颇尔’s highly successful Centramate™ and Centrasette™ products, and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.

 

T-Series cassettes for Centramate holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 93 cm² (0.1 ft²), making them ideal for process development and small-scale production of 50 mL to 125 L. Centrasette T-Series cassettes, in combination with Centrasette holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA.

Materials of Contruction

膜	Delta regenerated cellulose
支持	聚丙烯
Screens	聚丙烯
Encapsulent	Polyurethane with white pigment (TiO2)
Permeate Seals	Medical grade, platinum cured silicone
Gaskets	Medical grade, platinum cured silicone

 

Operating Limits

Maximum Pressure1	6 barg (90 psig) @ 23 °C 4 barg (60 psig) @ 55 °C
Maximum TMP	4 barg (60 psig) @ 55 °C
Temperature Range2	4 – 55 °C
pH 范围	2 – 13

¹ Pressure rating will be dependant on rating of the lowest system component.
² Cassettes must not be allowed to freeze.

 

Typical Operating Parameters

Cross Flow Rate for Processing	5 – 7 L/min/m2 (0.5 – 0.7 L/min/ft2)
Cross Flow Rate for Cleaning	5 – 8 L/min/m2 (0.5 – 0.8 L/min/ft2)

 

Integrity Test

Test Pressure	4 barg (60 psig)
Maximum Air Forward Flow	< 500 sccm/m2 (< 50 sccm/ft2)

 

Shelf Life

The shelf life of cassettes packaged in preservative is expected to be three years from the date of manufacture when the cassettes are stored unopened in the original packaging at 4 – 25 °C and protected from direct light.Extended shelf life studies are ongoing. 

 

Biological Safety

All of the materials of construction in the T-Series cassettes have been tested and meet requirements for United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo
<88> at 70 °C.

Each T-Series membrane cassette has a unique serial number for full traceability.Each cassette is supplied with:

• Certificate of Quality 
• Membrane Cassette Care and Use Procedures
• Material Safety Data Sheet (MSDS) for the cassette preservative
• Two platinum cured silicone gaskets

The full Validation Guide is available on request from your local 颇尔 contact.颇尔 also offers a comprehensive Validation Service for specific tests (such as compatibility) in your process fluid.As always, 颇尔’s Downstream Processing Specialists are available to train and support you in the optimization of your TFF processes.

T-Series Cassettes with Delta Low Protein Binding, Regenerated Cellulose Membrane

Part Number	NMWC*	Type and Nominal Membrane Area
DC010T01	10 kD	Centramate 93 cm2 (0.1 ft2)
DC010T02	10 kD	Centramate 186 cm2 (0.2 ft2)
DC010T12	10 kD	Centramate 0.1 m2 (1.1 ft2)
DC010T06	10 kD	Centrasette 0.5 m2 (5.4 ft2)
DC010T26	10 kD	Centrasette 2.5 m2 (27 ft2)
DC030T01	30 kD	Centramate 93 cm2 (0.1 ft2)
DC030T02	30 kD	Centramate 186 cm2 (0.2 ft2)
DC030T12	30 kD	Centramate 0.1 m2 (1.1 ft2)
DC030T06	30 kD	Centrasette 0.5 m2 (5.4 ft2)
DC030T26	30 kD	Centrasette 2.5 m2 (27 ft2)

*NMWC = Nominal Molecular Weight Cutoff

pall,颇尔,采用 Delta 再生纤维素膜的 T-系列 TFF 膜包