Automated chromatography columns
The Resolute Linear column range offers a unique combination of active multi-axis piston control, precision linear actuation and fully automated unit operations that delivers the following benefits to the end-user:
for pilot and process scale
- Fully scalable technology
- Quiet, clean operation
- Reduced operator involvement and error
- Predictable time efficient packing
A patented Resolute nozzle system is used with identical remote controlled three position nozzles at the top and bottom of the column.This technology allows packing and unpacking without opening the column.
Resolute Linear columns support both fixed and variable geometry pack in place methodology, however the platform has been specifically designed to fully exploit the capabilities of Resolute AutoPak; a one touch system for the fully automated packing, unpacking and CIP of the Resolute range of actuated columns.Where AutoPak is specified a packing skid is not required.
A standard Resolute Linear column comes with the Resolute AutoPak system, 20μm polyethylene sinters, an acrylic tube, 3 bar operating pressure and 100-400mm packed bed capability (100-500mm packed bed capability for non-AutoPak columns).
A range of material options and accessories is available to configure Resolute Linear to your requirements.
Multi-Axis ControlPrecision control of the piston is delivered by three linear actuators, which operate in unison through the control software to deliver class-leading piston movement stability.This technology is fully scalable across the entire range of columns.
The software actively monitors and controls the position of the actuators to ensure that the piston is always kept level.This provides a distinct advantage over central single actuator designs, where the piston is held level solely by passive seal action and design stiffness.
图 1：Cut through of a linear actuator
SoftwareIn a departure from more traditional HMI and control cabinet configurations, control of a Resolute Linear column is performed using a handheld touch screen remote control, from which the operator can initiate all the in-built Resolute functionality; including fully automated packing, unpacking, CIP and hoist-free maintenance.
The remote control is universal and can be used on all Resolute Linear columns.
The software is purpose coded for the remote control and is designed to be intuitive.For example, all operator actions and commands are a maximum of four clicks away from the home screen, making navigation and operation as easy as possible.
Integrated into the remote control is a safety enabled system that prevents operation while the operator is absent; this can be disabled on request.
图 2：Resolute Linear Remote Control
|Active multi-axis levelling control of piston, delivering class leading stability||Fully scalable column design, reduced risk of column damage over single axis designs|
|Electric only control unit and linear actuators||Small footprint, no cooling liquid required, no risk of oil leakage|
|In-built maintenance, enabling consumable change out from ground level||Safe operator environment, small cleanroom footprint|
|Intuitive software||Easier operator training, reduced risk of operator error|
Resolute Linear with AutoPakThe AutoPak system was developed in direct response to an industry need for fully automated operations.Often key column preparation operations, particularly packing, are regarded as high risk clean room events.These risks include human error, packing failure, and absence of experienced operators; they can result in plant downtime, loss of product or sorbent and inefficient use of resources.By adopting a fully automated approach, the AutoPak system greatly simplifies operation, effectively eliminates operator error and reduces the burden on key operators.The automated sequences assure that reproducible and consistent operation is the norm.
图 3：Typical Configuration Of A Resolute Linear Column With Integrated AutoPak
The scope of the installation below shows a Resolute Linear column with the AutoPak system, remote control and column mounted valve control accessory.The illustration should not be interpreted as a process and instrumentation diagram.
Hoist-Free Maintenance ModeAll Resolute Linear columns have a patented maintenance function in-built, allowing access to major consumable spare parts from ground level, without the need for an external crane or hoist.
The maintenance function provides:
- assured operator safety
- foot print efficiency
Maintenance schedules are advised in the operating manuals.
Wetted Pathway OptionsThe following wetted pathway options are available.
Wetted Stainless Steel Component Options*Can be applied to column tubes, bed supports, nozzle tubes and pipework kits.As standard, columns are supplied with 1.4404 components.
- not available for meshes
* Stainless steel options are quoted on request.
Bed Support Pore Size OptionsBed supports are available in 10 micron and 20 micron pore sizes.The mesh should be selected based on the sorbent average particle size; generally a bed support size < 1⁄3 of the average particle size is sufficient to prevent particle flow through.
For example, for a 90μm sorbent, 20μm bed supports would be specified, for a 34μm media 10μm bed supports would be specified.
Note that the difference between a 10 and 20 micron bed support pore size makes a negligible difference in overall column pressure drop.
表 1：Weights and DimensionsThe table below provides indicative dimensions and weights for the standard range.For additional diameters and bed heights, please contact your 颇尔 representative for an engineered solution.
Not Inc. Valves
|400 with AutoPak||700||840||1050||2000||2750||2550|
|450 with AutoPak||780||880||1050||2000||2750||2540|
|500 with AutoPak||860||920||1050||2000||2750||2530|
|600 with AutoPak||1030||1010||1060||2000||2750||2510|
|630 with AutoPak||1270||1100||1150||2040||2790||2560|
|700 with AutoPak||1520||1180||1250||2070||2820||2600|
|800 with AutoPak||2010||1360||1450||2140||2890||2700|
|900 with AutoPak||2370||1440||1480||2150||2900||2700|
|1000 with AutoPak||2730||1510||1510||2160||2910||2700|
|1200 with AutoPak||4250||1800||1780||2410||3160||2960|
|Process Wetted Fixed Components||Material|
|Column tube||Acrylic (PMMA) / Stainless Steel*|
|Nozzle body||480 – 1000 mm Ø Column:PVDF|
|1200 mm Ø Column:聚丙烯|
|Mobile phase termination||480 – 1000 mm Ø Column:PEEK|
|1200 mm Ø Column:Stainless Steel 316L|
|Slurry nozzle tip||PEEK|
|Slurry inlet port||400 – 1200 mm Ø Column:Stainless Steel 316L*|
|Main seals||EPDM (Peroxide Cured) / FEP|
|Nozzle tip seals||FEP Encapsulated Silicone|
All non-wetted materials are suitable for wipe down and clean room use.
* Different grades of stainless steel are available.See Wetted Pathway Options.
表 3：Standard Surface Finishes
|Non-wetted||1.5 micron Ra|
|Wetted||0.5 micron Ra|
|Acrylic (PMMA)||Polished smooth|
*Improved surface finishes quoted on request.
表 4：Operating Temperature
|Ambient Temperature Ranges|
|Operating Temperature Static*||2 - 30 ºC|
|Operating Temperature Dynamic**||15 - 25 ºC|
* The static temperature range refers to when the column is in process mode and no piston movement will take place.
** The dynamic temperature range refers indicates the acceptable temperature range when the column piston is moving.
Temperature ranges outside of these values above are quoted upon request.Columns can be designed for operational ranges up to 60 degrees C.
Certification & Technical Construction FileResolute Linear columns can be designed to meet either of the following pressure vessel codes.
Asme Boiler & Pressure Vessel Code 2013 addition.
PD 5500:2012 + A2:2013
All columns and accessories come with a full technical documentation file.Examples are available on request.
Linear Remote ControlThe remote control is the master controller for Resolute Linear column and allows the full scope of operations to be initiated and monitored.
At least one remote control must be purchased for each set of columns.If packing, unpacking or CIP is to take place simultaneously on more than one column, then additional remote control(s) should be purchased as required.
图 4：Resolute Linear Remote Control
Column Mounted Valve ControlThe touch screen device is fitted permanently to the column, and allows the process valving and nozzles to be controlled when the remote control unit is not connected.This permits the remote control unit to be used with other columns.
This option should be obtained when multiple columns are purchased and only one column is packed at a time.
Resolute Linear Column
Mounted Valve Control Kit
图 5：Column Mounted Valve Control
AutoPak Tank Valve BlockThe AutoPak tank valve block provides the ability to switch between buffer and slurry while controlling the agitation in the tank.Included with the column is the valve block, mounting, hoses to connect to the column tanks and associated clamps and EPDM gaskets.As standard, pipework and GEMU block valves are included in 316L (1.4404) stainless steel.If an alternative stainless steel is selected then the material change must be stated at the point of order.
At least one AutoPak tank valve block must be purchased for each set of AutoPak columns.
If packing, unpacking or CIP is to take place simultaneously on more than one column, then additional valve blocks should be purchased as necessary.
|TVB-1||AutoPak Tank Valve Block||<800|
|TVB-2||AutoPak Tank Valve Block||大于10000|
Resolute Drive StationThe Resolute Linear Drive Station supplies the power and drive control for the three linear actuators.
One Drive Station can operate all columns sizes, therefore, at least one drive station must be purchased for each set of columns.If packing, unpacking or CIP is to take place simultaneously on more than one column, then additional drive stations are required as necessary.The drive station is not required when the column is in process mode.However a separate 24V power supply will be required to operate valves and nozzles using the Resolute Linear Remote Control or Column Mounted Valve Control.
The external material of the cabinet is stainless steel, suitable for wipedown, and use in a clean environment.The cabinet is rated to the requirements IP65.The drive station is a discrete unit which occupies minimal floor space and requires only an electrical supply to operate.
|EPU||Resolute Linear Drive Station||全部|
图 6：Resolute Drive Station
Non-AutoPak Valve KitsFor Resolute Linear columns that are selected without the AutoPak system, a valve kit is available to facilitate process and packing connections.This kit enables manual selection of column online and bypass modes and provides the required burst disk* pressure relief.It is recommended for both chromatography skid connection and packing operations.
As standard, pipework and GEMU block valves are included in 316L (1.4404) stainless steel with all necessary EPDM gaskets, clamps and mounting brackets.If an alternative stainless steel is selected then the material must be stated at the point of order.
This kit is factory fitted, and shipped with the column.
Resolute Linear Pipe
and Manual Valving Kit
* Pressure relief valves can be quoted on request.
**XXXX = column diameter in mm
Additional AccessoriesOther accessories such as column transport options, slurry tanks, packing skids, bed support transporters and media handling solutions are available upon request.Please contact 上海羽令 or www.yl-guolv.com for more information.
|ADJ PE bed support 20µm kit||EEA14A136A13||EEA14A136A27||EEA14A136A37|
|ADJ PE bed support 20µm kit||EEA14A139A13||EEA14A139A27||EEA14A139A37|
|FIXED PE bed support 20µm kit||EEA14A142A13||EEA14A142A27||EEA14A142A37|
|FIXED 316L bed support 20µm kit||EEA14A145A13||EEA14A145A27||EEA14A145A37|
|Snap ring for PE sinters||K400-3033||联系我们||联系我们|
|Snap ring for SS meshes||K400-3012||K450-4058||K500-3011-03|
|Wiper ring for PE sinters||EEA12A181A129||EEA12A181A252||EEA12A181A253|
|Wiper ring for SS meshes||EEA12A181A129||EEA12A181A252||EEA12A181A253|
|Major seal kit (adjuster main seals and fixed end main seals)||EEA12A155A129||EEA12A155A252||EEA12A155A253|
|Intermediate fixing screw kit||不可用||不可用||不可用|
|Nozzle tip kit||EEA13A159A20||EEA13A159A20||EEA13A159A21|
|Nozzle valve seal kit||EEA12A152A20||EEA12A152A20||EEA12A152A21|
|ADJ PE bed support 20µm kit||EEA14A136A14||EEA14A136A189||EEA14A136A227|
|ADJ 316L bed support 20µm kit||EEA14A139A14||EEA14A139A189||EEA14A139A227|
|FIXED PE bed support 20µm kit||EEA14A142A14||EEA14A142A189||EEA14A142A227|
|FIXED 316L bed support 20µm kit||EEA14A145A14||EEA14A145A189||EEA14A145A227|
|Snap ring for PE sinters||K600-3013||联系我们||联系我们|
|Snap ring for SS meshes||K600-3012||K630-3025||K700-3073-01|
|Wiper ring for PE sinters||EEA12A181A130||EEA12A181A254||EEA12A181A255|
|Wiper ring for SS meshes||EEA12A181A130||EEA12A181A254||EEA12A181A255|
|Major seal kit (adjuster main seals and fixed end main seals)||EEA12A155A130||EEA12A155A254||EEA12A155A255|
|Intermediate fixing screw kit||不可用||不可用||EEA13A220A15|
|Nozzle tip kit||EEA13A159A21||EEA13A159A21||EEA13A159A21|
|Nozzle valve seal kit||EEA12A152A21||EEA12A152A21||EEA12A152A21|
|ADJ PE bed support 20µm kit||EEA14A136A15||EEA14A136A16||EEA14A136A17|
|ADJ 316L bed support 20µm kit||EEA14A139A15||EEA14A139A16||EEA14A139A17|
|FIXED PE bed support 20µm kit||EEA14A142A15||EEA14A142A16||EEA14A142A17|
|FIXED 316L bed support 20µm kit||EEA14A145A15||EEA14A145A16||EEA14A145A17|
|Snap ring for PE sinters||K800-3075-01||K1000-3023-02||K1200-3067|
|Snap ring for SS meshes||K800-3249||K1000-3023||K1200-3039|
|Wiper ring for PE sinters||EEA12A181A131||EEA12A181A132||EEA12A181A133|
|Wiper ring for SS meshes||EEA12A181A131||EEA12A181A132||EEA12A181A133|
|Major seal kit (adjuster main seals and fixed end main seals)||EEA12A155A131||EEA12A155A132||EEA12A155A133|
|Intermediate fixing screw kit||EEA13A220A15||EEA13A220A16||EEA13A220A17|
|Nozzle tip kit||EEA13A159A22||EEA13A159A24||EEA13A159A23|
|Nozzle valve seal kit||EEA12A152A22||EEA12A152A24||EEA12A152A23|