Polymeric Membrane Morphology
Microza* ultrafiltration membranes are unique in their construction.Every membrane has an asymmetric structure,with a membrane layer both on the inside, and on the outside of the fiber, overlaying a core comprising a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service.Microza ultrafiltration membranes are resistant to flow in both directions, so there is no risk of delamination or membrane rupture during accidental back-pressure.实际应用中，在许多装置内，可使用反冲恢复和保持长期运行期间的流量。
Microza micofiltration membranes have smooth inner and outer membrane skins with a highly porous symmetrical support structure giving high-flow rates.这类膜柱还可进行反冲洗。
All Microza membranes have surfaces that minimize entrapment and facilitate cleaning.所有 Microza 膜皆一步生产成型，且不含叠层。Membranes and modules are subjected to rigorous quality control to ensure consistency of performance, durability in service, and module integrity for the most demanding applications.
Polsulfone (PS)
聚砜膜具有良好的抗压、耐温以及抵抗破坏性清洁等卓越性能，Very low affinity and adsorption characteristics results in high product recoveries, and long service life.
Microza SP, SV and VP series hollow fiber ultrafiltration modules have a unique double-skinned proprietary polysulfone (PS) membrane with dense internal layer.Currently available in 3000, 4000, 6000, and 10000 molecular weight cut-offs, the modules are used in a range of pharmaceutical applications including pyrogen removal from water, buffer solutions active ingredients such as antibiotics, and concentration of protein solutions.SV modules are used for clarifying antibiotic and other broths used for small molecule active pharmaceuticals ingredients production.
Key Features
- Combination of high-strength and high-flow due to unique membrane construction
- Double-skin provides assurance of removal rating
- High-strength fiber allows reverse filtration to assist cleaning in difficult applications
- Available in a range of sizes from 0.015 m2 (0.16 ft2) to more than 12 m2 (125 ft2)
- All SP and VP modules may be hot water sanitized:up to 95 °C – SIP and SLP, or 90 °C – SEP and SAP; and all may run continuously at 80 °C
- SP Modules may be autoclaved in single use applications
- VIP 6000 MWCO version steam-sterilizable up to 50 cycles at 125 °C at a differential pressure of 100 mbar
- SV modules are designed for maximized recovery in bulk fermentation, limited to 50 °C
- Compatible with a wide range of cleaning agents, up to 5000 ppm sodium hypochlorite or 4% sodium hydroxide
- Meets the specification for biological tests listed in the current revision of USP for class VI plastics at 121 °C
- pH range 1 – 14
Microza Module Types
Microza hollow fiber modules are available with housings made from polysulfone (native, clear), filled polysulfone (white, opaque), and polyvinylchloride (PVC).Polysulfone modules will withstand autoclaving and in some cases steaming.Clear polysulfone modules are recommended for more critical pharmaceutical applications.Filled polysulfone and PVC modules are ideally suited to long term installations where light might cause biofilm to form, or for bulk processes involving light sensitive materials.PVC modules are idea for use in feed water systems and bulk processes.
Microza modules are available with industry standard clamp fittings on the feed and retentate side, and some with quick connects.All steamable modules designed for long term use in critical applications such as perfusion have sanitary clamp connections on the feed/retentate and filtrate sides, or filtrate hose barbs on laboratory scale modules.
Retrofitting Existing Applications
To retrofit an existing application,membrane rating should be chosen to be equivalent or superior in performance.For ultrafiltration membranes, this may require testing more than a single cut-off.Differences in membrane area and lumen diameter can typically be accommodated by adjustments to operating conditions to ensure that trans-membrane pressure and fluid velocity conditions at the membrane surface are similar.Hollow fiber modules can be joined end-to-end as required to create similar path length systems.Small adjustments to physical dimensions, and differences in connection type are accomplished using adapters.Please contact 上海羽令 for assistance with selecting the right modules to retrofit an existing installation.* Microza is a trademark of Asahi Kasei Corporation
材料成分
| 膜 | Polysulfone (with silicone coating on ends in VIP–3017S) |
| 滤壳 | Native clear polysulfone (P) or PVC (V) |
| Potting Material | 环氧树脂 |
| Gasket | Silicone (P) or butyl rubber (NBR) (V) |
| Bacteriostat | Glycerin 65%, Ethanol 2%, water balance |
Connectors and Adapters
| A - A1 | Small hose barb 4.5 mm (3/16 in.) |
| A2 | Small hose barb 6 mm (¼ in) |
| B - B1 |
Quick connect -To convert feed/retentate to: |
| C - C3 | 1 in. sanitary flange (ferrule face 34 mm [1.34 in.]) |
| C4 | 1½ in. sanitary flange (ferrule face 50 mm [1.98 in.]) |
| C5 | 2 in. sanitary flange (ferrule face 64 mm [2.52 in.]) |
| C7 | 4 in. sanitary flange (ferrule face 117 mm [4.61 in.]) |
| C8 | 6 in. sanitary flange (ferrule face 157 mm [6.18 in.]) |
| D - D2 | Cap nut, 38.5 mm diameter |
| D3 | Cap nut, 48.5 mm diameter |
Part Numbers and Technical Specification - Table 1 1
| Part Number |
Rating (MWCO, Daltons) |
Fiber ID / OD |
Nominal Length (2) (mm) |
Membrane Area (m2) |
Clean Water Flux Lh-1 bar, 25 oC |
Crossflow Rate for 1ms-1 fluid velocity |
| SEP-0013 | 3000 | 0.7 / 1.3 mm | 130 | 0.017 | 2.2 | 181 |
| SEP-1013 | 3000 | 0.8 / 1.4 mm | 347 | 0.19 | 25 | 724 |
| SEP-2013 | 3000 | 0.8 / 1.4 mm | 552 | 1.0 | 130 | 1629 |
| SEP-3013 | 3000 | 0.8 / 1.4 mm | 1129 | 4.7 | 650 | 3655 |
| SAP-0013 | 4000 | 0.7/ 13 mm | 130 | 0.017 | 3.6 | 181 |
| SAP-1013 | 4000 | 0.8 / 1.4 mm | 347 | 0.19 | 36 | 724 |
| SAP-3013 | 4000 | 0.8 / 1.4 mm | 1129 | 4.7 | 900 | 3655 |
| SAV-3013 | 4000 | 0.8 / 1.4 mm | 1126 | 5.6 | 1100 | 4343 |
| SAV-5013 | 4000 | 0.8 / 1.4 mm | 1126 | 12.1 | 2400 | 9950 |
| SIP-0013 | 6000 | 0.8 / 1.4 mm | 130 | 0.017 | 3.4 | 181 |
| SIP-1013 | 6000 | 0.8 / 1.4 mm | 347 | 0.19 | 40 | 724 |
| SIP-1023 | 6000 | 0.8 / 1.1 mm | 347 | 0.19 | 44 | 724 |
| SIP-2013 | 6000 | 0.8 / 1.4 mm | 552 | 1.0 | 200 | 1629 |
| SIP-3013 | 6000 | 0.8 / 1.4 mm | 1129 | 4.7 | 1000 | 3655 |
| SIP-3023 | 6000 | 0.8 / 1.1 mm | 1129 | 7.2 | 1700 | 5610 |
| VIP-3017S(4) | 6000 | 0.8 / 1.4 mm | 1129 | 4.7 | 1000 | 3655 |
| SLP-0053 | 10000 | 1.4 / 2.3 mm | 130 | 0.015 | 4.1 | 277 |
| SLP-1053 | 10000 | 1.4 / 2.3 mm | 347 | 0.12 | 40 | 776 |
| SLP-2053 | 10000 | 1.4 / 2.3 mm | 552 | 0.6 | 150 | 1773 |
| SLP-3053 | 10000 | 1.4 / 2.3 mm | 1129 | 4.5 | 1500 | 5819 |
Part Numbers and Technical Specification - Table 2 1
| Part Number | Maximum Pressure (barg) Feed/TMP/Permeate at 50 oC | Volume Feed Side (3) (mL) | Volume Permeate Side (3) (mL) | Feed/Retentate Connection | Permeate Connection |
| SEP-0013 | 1/1/1 | 9 | 9 | A2 | A1 |
| SEP-1013 | 3/3/2 | 90 | 120 | B1 | B1 |
| SEP-2013 | 5/3/2 | 300 | 500 | C4 | C3 |
| SEP-3013 | 5/3/3 | 1200 | 3700 | C5 | C4 |
| SAP-0013 | 1/1/1 | 9 | 9 | A2 | A1 |
| SAP-1013 | 3/3/2 | 90 | 120 | B1 | B1 |
| SAP-3013 | 5/3/3 | 1200 | 3700 | C5 | C4 |
| SAV-3013 | 5/3/3 | 1200 | 3700 | C7 | D2 |
| SAV-5013 | 5/3/3 | 3800 | 5300 | C8 | D3 |
| SIP-0013 | 1/1/1 | 9 | 9 | A2 | A1 |
| SIP-1013 | 3/3/2 | 90 | 120 | B1 | B1 |
| SIP-1023 | 3/3/2 | 90 | 130 | B1 |
B1 |
| SIP-2013 | 5/3/2 | 300 | 500 | C4 | C3 |
| SIP-3013 | 5/3/3 | 1200 | 3700 | C5 | C4 |
| SIP-3023 | 5/3/3 | 700 | 3700 | C5 | C4 |
| VIP-3017S(4) | 5/3/3 | 1200 | 3700 | C5 | C4 |
| SLP-0053 | 1/1/1 | 11 | 9 | A2 | A1 |
| SLP-1053 | 3/3/2 | 85 | 120 | B1 | B1 |
| SLP-2053 | 5/3/2 | 310 | 500 | C4 | C3 |
| SLP-3053 | 5/3/3 | 1850 | 3700 | C5 | C4 |
(2) Nominal length is flange to flange, or to ends of connectors on quick-connect modules.Detailed drawings available upon request.
(3) Guideline module filling volume to allow calculation of minimum system working volumes when added to volumes of attached piping and other components.Draining residual volumes are considerably less.
(4) VIP-3017S - Maximum inlet pressure for steam at 121 oC is 1.1 barg, max TMP 0.1 barg, filtrate pressure ) (open steaming, no back pressure)
