pall,颇尔,Mustang 层析囊式过滤器和滤芯,

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Mustang 层析囊式过滤器和滤芯
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pall,颇尔,Mustang 层析囊式过滤器和滤芯,
pall,颇尔,Mustang 层析囊式过滤器滤芯

Mustang 层析<a href='http://pall.net.cn/' target='_blank'>囊式过滤器</a>和滤芯
Combining high-capacity, ion-exchange Mustang membranes with a unique 16-layer open-pleat design results in a high-flow rate, high-capacity, single-use, versatile range of pleated products that can be used for a wide range of applications.

This 16-layer construction is held constant from the laboratory-scale Mustang XT Acrodisc Unit to the largest industrial process-scale capsule, ensuring constant chromatography bed depth in all formats.Mustang E capsules use three layers of a standard pleat format membrane to remove endotoxin from process feedstreams.The three-layer construction is held constant from the Mustang E Acrodisc® format to the largest industrial process scale capsule.

The ease of linear scale-upensures a shortened process development time by significantly reducing the re-optimization required between scale-up steps.These units are specifically designed for single-use.This eliminates cleaning and the costs associated with cleaning validation.Mustang capsules are fully self-contained units that connect directly into a system using 18 mm (1.5 in.) sanitary flange connectors.Mustang cartridges require the use of a Code 7 housing which requires cleaning and reassembly after each use.

 

Mustang Q Membrane

Mustang Q membrane is an anion-exchange support with pendant quaternary amine functional groups in a cross-linked polymeric coating on a 0.8 micron pore-size membrane.This gives high dynamic capacities for high molecular weight products such as DNA, plasmids or even particles as large as viruses.

Mustang S Membrane

Mustang S membrane is a cation-exchange support with pendant sulfonic functional groups in a cross-linked polymeric coating on a 0.65 µm pore-size membrane.This gives high dynamic capacities for high molecular weight products such as IgG, Factor VIII and some viruses.

 

Mustang E Membrane

Mustang E membrane is a highly cross-linked quaternized amine charge polymer coating on a 0.2 micron pore size membrane.This gives very high dynamic capacities, under selected conditions for the removal of endotoxin from process feedstreams, buffers and water.

 

特色及优点

  • Binding Efficiency:charged biomolecules are readily bound in a single pass
  • Speed:high-flow rates enable the processing of large volumes in less than a single working shift.Mustang units typically operate at flow rates between 10 to 40 membrane volumes per minute, making them much faster than conventional columns which typically operate at 0.5 column volumes per minute
  • Scalability:full range of sizes accommodates the different volumes and capacities required in biopharmaceutical processing
  • Convenience:ready to use, autoclavable and disposable to eliminate potential packing, cleaning, validation and cross-contamination issues
  • 灵活性优势available in capsule or cartridge format
  • Cost:lower operating costs and capital investment compared to conventional columns that need validated packing and cleaning

High Quality Standards

  • Manufactured to high quality assurance standards in accordance with ISO 9000
  • Membrane lots tested for dynamic protein binding capacity, and peak position using standard proteins
  • Identified by lot number and unique serial number for complete traceability of manufacturing history, satisfying stringent QC/QA requirements
  • Supplied with Certificate of Analysis to confirm quality control
  • Meets USP Biological reactivity tests in vivo in accordance with USP Class VI 50 ºC and all materials listed in Drug Master File submitted to the FDA

Comprehensive Validation

  • Extensive validation to ensure consistent and reliable performance
  • A comprehensive validation guide is available for each of the membrane chemistries on request

Products in this datasheet may be covered by one or more patents including :
EP 1 189 685
US 6,849,185
US 7,189,322

 
 

Mustang 囊式过滤器

 

材料成分

 
项目 CLxMSTG*P1 NPxMSTG*P1
Modified hydrophilic polyethersulfone Modified hydrophilic polyethersulfone
Membrane Support and Drainage Layer Assembly 聚丙烯 聚丙烯
Core and Cage 聚丙烯 聚丙烯
Endcaps and Adapters 聚酯 聚酯
Housing Bowl Polyetherimide 聚丙烯
Housing Head Polyetherimide with TiO2 Polypropylene with TiO2
O 型圈 Silicone elastomer Silicone elastomer
 

注意事项:
For CLxMST*P1, x =
M05 for a Q, S or E unit with a bed volume of 10 mL
3 for a Q or S unit with a bed volume of 60 mL or an E unit with a bed volume of 40 mL

For NPxMSTG*P1, x =
6 for a Q or S unit with a bed volume of 260 mL or an E unit with a bed volume of 160 mL
7 for a Q or S unit with a bed volume of 520 mL or an E unit with a bed volume of 320 mL
8 for a Q or S unit with a bed volume of 780 mL or an E unit with a bed volume of 480 mL

* =
Q for a unit with Q (quaternary amine) chemistry membrane
S for a unit with S (sulfonic acid) chemistry membrane
E for a unit with E (polyethyleneimine) chemistry membrane

Nominal Dimensions

 
Capsule Type CLM05MSTG*P1 CL3MSTG*P1 NP6MPSTG*P1 NP7MSTG*P1 NP8MSTG*P1
Maximum Diameter (inc.Valves) 123 mm (4.8 in.) 123 mm (4.8 in.) 154 mm (6.1 in.) 154 mm (6.1 in.) 154 mm (6.1 in.)
Length with Sanitary Flange Fittings 84 mm (3.3 in.) 157 mm (6.2 in.) 335 mm (13.2 in.) 581 mm (22.9 in.) 831 mm (32.7 in.)
Bed Volume 10 毫升 Q and S = 60 mL
E = 40 mL
Q and S = 260 mL
E = 160 mL
Q and S = 520 mL
E = 320 mL
Q and S = 780 mL
E = 480 mL
 

* Q for a unit with Q (quaternary amine) chemistry membrane; S for a unit with S (sulfonic acid) chemistry membrane; E for a unit with E (polyethyleneimine) chemistry membrane

Operating Characteristics¹

 
Maximum Operating Pressure; Maximum Differential Pressure 4.1 bar (59.5 psi) at 38 °C
Maximum Sanitization Conditions 1 N NaOH for 30 minutes for one cycle only
Maximum Autoclave Conditions 121° C for 30 minutes for one cycle only
 

¹ With fully compatible fluids that do not soften, swell or adversely affect the capsule or its materials of construction

Typical Binding Characteristics

 
Chemistry Molecule MW or Size CLM05 CL3 NP6 NP7 NP8
Q BSA 65 kD 0.5 – 0.6 g 3.0 – 3.6 g 13 – 16 g 26 – 31 g 39 – 47 g
Q Thyroglobulin 650 kD 0.3 g 1.8 g 7.8 g 15.6 g 23.4 g
DNA - 0.20 – 0.25 g 1.2 – 1.5 g 5.2 – 6.5 g 10.4 – 13.0 g 15.6 – 19.5 g
Plasmid DNA 4.5 kb plasmid 0.15 g 0.9 g 3.9 g 7.8 g 11.7 g
Plasmid DNA 12 kb plasmid 0.15 g 0.9 g 3.9 g 7.8 g 11.7 g
Adenovirus 70 – 90 nm 5 x 1013 viral particles 3 x 1014 viral particles 1.3 x 1015 viral particles 2.6 x 1015 viral particles 3.9 x 1015 viral particles
Lysozyme 14.3 kD 0.45 – 0.50 g 2.7 – 3.0 g 11.7 – 13.0 g 23.4 – 26.0 g 35.1 – 39.0 g
S Human IgG 160 kD 0.2 g 1.2 g 5.2 g 10.4 g 15.6 g
E Endotoxin Units   4 x 107 EU/capsule 1.6 x 108 EU/capsule 6.4 x 108 EU/capsule 1.28 x 109 EU/capsule 1.92 x 109 EU/capsule
 

 

Mustang Cartridges

 

材料成分

 
项目 ABxMSTG*7PH4
Modified hydrophilic polyethersulfone
Membrane Support and  Drainage Layer Assembly 聚丙烯
Core and Cage 聚丙烯
Endcaps, Adapters and Bomb Fins 聚酯
O 型圈 Silicone elastomer
 

x = 1 for a 254mm (10 in.)Q or S unit with a bed volume of 260 mL
 2 for a 508 mm (20 in.)Q or S unit with a bed volume of 520 mL
 3 for a 762 mm (30 in.)Q or S unit with a bed volume of 780 mL
* = Q for a unit with Q (quaternary amine) chemistry membrane
 S for a unit with S (sulfonic acid) chemistry membrane

Operating Characteristics²

 
最大操作压力  3 bar (43.5 psi) at 38 °C
Maximum Differential Pressure 3 bar (43.5 psi) at 38 °C 
Maximum Sanitization Conditions Conditions 1 N NaOH for 30 minutes for one cycle only
Maximum Autoclave Conditions 121 °C for 30 minutes one cycle only
 

² With fully compatible fluids that do not soften, swell or adversely affect the capsule or its materials of construction

Nominal Dimensions

 
Cartridge Type Diameter Length Bed Volume
AB1MSTG*7PH4  70 mm (2.75 in.) 254 mm (10 in.) 260 毫升
AB2MSTG*7PH4 70 mm (2.75 in.) 508 mm (20 in.) 520 毫升
AB3MSTG*7PH4 70mm (2.75 in.) 762 mm (30 in.) 780 毫升
 

* = Q for a cartridge with Q (quaternary amine) chemistry membrane; S for a cartridge with S (sulfonic acid) chemistry membrane

Typical Binding Characteristics

 
Chemistry Molecule MW or Size AB1 AB2 AB3
Q BSA 65 kD 13 – 16 g 26 – 31 g 39 – 47 g
Q Thyroglobulin 650 kD 7.8 g 15.6 g 23.4 g
Q DNA - 5.2 – 6.5 g 10.4 – 13.0 g 15.6 – 19.5 g
Plasmid DNA 4.5 kb plasmid 3.9 g 7.8 g 11.7 g
Plasmid DNA 12 kb plasmid 3.9 g 7.8 g 11.7 g
Q Adenovirus 70 – 90 nm 1.3 x 1015 viral particles 2.6 x 1015 viral particles 3.9 x 1015 viral particles
Lysozyme 14.3 kD 11.7 – 13.0 g 23.4 – 26.0 g 35.1 – 39.0 g
S Human IgG 160 kD 5.2 g 10.4 g 15.6 g
 

Mustang 囊式过滤器

 
Chemistry Bed Volume Pack Quantity Part Number 描述
Q 10 毫升 1 CLM05MSTGQP1 38 mm (1.5 in.) sanitary connectors, in-line capsule
Q 60 毫升 CL3MSTGQP1 38 mm (1.5 in.) sanitary connectors, in-line capsule
Q 260 毫升 1 NP6MSTGQP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
Q 260 毫升 1 NT6MSTGQP1 38 mm (1.5 in.) sanitary connectors, T-style capsule 
Q 520 毫升 1 NP7MSTGQP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
Q 520 毫升 1 NT7MSTGQP1 38 mm (1.5 in.) sanitary connectors, T-style capsule 
Q 780 毫升 1 NP8MSTGQP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
S 10 毫升 1 CLM05MSTGSP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 

60 毫升 1 CL3MSTGSP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
S 260 毫升 1 NP6MSTGSP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
S 520 毫升 NP7MSTGSP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
S 780 毫升 1 NP8MSTGSP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
10 毫升 1 CLM05MSTGEP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
E 40 毫升 1 CL3MSTGEP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
160 毫升 1 NP6MSTGEP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
320 毫升 1 NP7MSTGEP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
E 480 毫升 1 NP8MSTGEP1 38 mm (1.5 in.) sanitary connectors, in-line capsule 
 

Mustang Cartridges

 
Chemistry Bed Volume Pack Quantity Part Number 描述
Q 260 毫升 1 AB1MSTGQ7PH4 254 mm (10 in.) cartridge element with Code 7 adapter
Q 520 毫升  1 AB2MSTGQ7PH4 508 mm (20 in.) cartridge element with Code 7 adapter
780 毫升 1 AB3MSTGQ7PH4 762 mm (30 in.) cartridge element with Code 7 adapter
S 260 毫升  1 AB1MSTGS7PH4 254 mm (10 in.) cartridge element with Code 7 adapter
S 520 毫升  1 AB2MSTGS7PH4 508 mm (20 in.) cartridge element with Code 7 adapter
S 780 毫升  1 AB3MSTGS7PH4 762 mm (30 in.) cartridge element with Code 7 adapter
 

 


pall,颇尔,Mustang 层析囊式过滤器滤芯
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