pall,颇尔,切向流过滤膜包夹具,FS002K10, FS013K10, CM018LV, FS001K10, FS011K10, FS001K05, FS039K05, FS044K05, FS046K05, FS001K05, FS014K05, FS020K05, FS022K05, FS050K05, FS034K05, FS036K05, FS038K05, FS001G01, FS0

pall,颇尔,切向流过滤膜包夹具

Choosing a Cassette Holder

Designed for optimum performance and product recovery 颇尔 TFF cassette holders are available in a variety of sizes to meet every application requirement.This way applications that are developed on a small system using a Centramate or Maximate cassette can be easily scaled up, either by adding additional cassettes to the holder or by scaling into a larger cassette format and holder configuration with identical flow path like the Centrasette/Centrastak™ or Maxisette holders. 

 

Holder Sizes

TFF cassette holders for the medium and large-scale production environment have a small footprint, yet still are capable of holding large areas of membrane. All stainless steel holders are engineered to precise specifications with a high standard internal and external surface finish and are available with either manual torque (MT) or auto torque (AT) compression systems for ease of use. Operators must use calibrated torque wrenches (supplied with the holder) to effect required compression of cassettes and gaskets in a manual torque cassette holder. 

 

Auto-torque Feature

Auto-torque cassette holders automatically compensate for cassette compression and temperature reduction.They also eliminate variability in technique between operators.Auto-torque cassette holders are recommended for process-scale validated processes.
Sanitary stainless steel holders may be sterilized by steam or autoclaving without cassettes installed. 

 

Fittings Kits

Complete fittings kits consisting of pressure gauges, valves, filtrate manifold, connectors, gaskets and clamps are available for most cassette holders.Ordering a complete fitting kit with the cassette holder simplifies installation into a system and avoids potential delays in starting your process due to missing parts.

View additional Tangential Flow Filtration Systems and Components.

• TFF Membrane Cassette Holder Information
• Selection of Holders
• Technical Specifications

 

TFF Membrane Cassette Holder Information

The following tables list cassette holders with relative area capacities (screen channel cassettes) and working volumes¹.

The Minimate™ TFF Capsule is also included to complete the range of lab scale products.

Lab and Development Scale Holders

产品	Membrane Area (Nominal m2)1	MembraneArea (Nominal ft2)1	Working Volume Start2	Working Volume Final2
Minimate TFF 超滤膜包	0.005 m2	0.05 ft2	25 - 500 毫升	15 毫升
Centramate LV	0.01 - 0.04 m2	0.1 - 0.4 ft2	25 - 4,000 毫升	15 毫升
Centramate PE	0.01 - 0.37 m2	1 - 4 ft2	0.5 - 80 L	150 毫升
Centramate	0.1 - 0.5 m2	1 - 5 ft2	0.5 - 100 L	150 毫升
Maximate	0.19 - 1.11 m2	2 - 12 ft2	1 - 250 L	350 毫升

 

Pilot Scale (Process Development)

产品	Membrane Area (Nominal m2)1	MembraneArea (Nominal ft2)1	Working Volume Start2	Working Volume Final2
Centrasette LV	0.46 - 2.0 m2	5 - 22 ft2	2.5 - 500 L	400 毫升
Centrasette P	0.46 - 2.0 m2	5 - 22 ft2	2.5 - 500 L	400 毫升
Centrasette 5	0.46 - 4.6 m2	5 - 50 ft2	2.5 - 1,000 L	1, 000 mL

 

Process Scale (Production)

产品	Membrane Area (Nominal m2)1	MembraneArea (Nominal ft2)1	Working Volume Start2	Working Volume Final2
Centrastak 100	0.9 - 20.0 m2	10 - 215 ft2	10 - 4,000 L	4 L
Centrastak 200	1.85 - 40.0 m2	20 - 430 ft2	20 - 8,000 L	10 L
Centrastak 300	2.8 - 60.0 m2	30 - 645 ft2	30 - 12,000 L	15 L
Centrastak 400	3.7 - 80.0 m2	40 - 860 ft2	40 - 16,000 L	20 L
Maxisette 25	2.8 - 27.9 m2	30 - 300 ft2	30 - 6,000 L	15 L
Maxisette 50	5.6 - 55.8 m2	60 - 600 ft2	60 - 12,000 L	30 L
Maxisette 100	5.6 - 92.9 m2	60 - 1,000 ft2	60 - 20,000 L	40 L

1. Fewer suspended screen cassettes will fit due to increased thickness.Some holders can fit more membrane area than can be operated at required cross flow rates due to high pressure drops.Do not use more than the recommended area in these holders.Manual (MT) and auto-torque (AT) version holders are available for Pilot and Process Scale applications.

2. Working Volumes are based on an average filtrate flux rate of about 50 LMH and process time of 5 hours.Starting Range covers minimum to maximum area installed for screen channel cassettes.Final process volume represents final concentration volume or minimum working volume for the system.Actual volumes depend on system hold-up volume and operating parameters.Piping (tubing) lengths and internal diameters significantly affect the final volume.

 

Selection of Holders

Centramate LV Holder

The Centramate LV holder is fabricated from Stainless Steel (316L) with female luer fittings for use with 0.01 m² (0.1 ft²) and 0.02 m² (0.2 ft²) Centramate cassettes.The holder can accommodate up to 0.04 m² (0.4 ft²) of screen channel or 0.02 m² (0.2 ft²) of open channel Centramate cassettes at recommended cross flow rates.A range of luer fittings and valves are available as well as pressure gauges or transducers to set-up a complete TFF system.

 

 

 

 

Centramate PE Holder

Centramate PE 支架设有一根 ¼ 英寸的聚乙烯导流管。NPT threaded ports sandwiched between 304 stainless steel outer plates for support.It accommodates up to 4 screen channel (3 suspended screen channel) 0.09 m² (1 ft²) cassettes.The use of spacers on the tie rods makes it easy to apply and tighten the nuts with minimal threading if only one cassette is installed.As additional cassettes are added, spacers can be removed.The Centramate PE holder is recommended for use in applications where metal contact must be avoided.A plastic, NPT threaded fitting kit, with either 2 or 3 pressure gauges is available. 

 

 

Centramate Stainless Steel Holder

The Centramate stainless steel cassette holder (316L) comes with ½ in. sanitary flanges on feed and filtrate ports. The holder is supplied with surface and weld certification.Up to 5 screen channel (4 suspended screen channel) 0.09 m² (1 ft²) cassettes can be accommodated.Holder is supplied with both 1 in. and 2 in. spacers on the tie rods to simplify cassette installation and to apply the required torque.Spacers can be removed to compensate for the height difference as additional cassettes are added to the holder.Sanitary fitting kits with either 2 or 3 pressure gauges are available.    

 

 

Centrasette P Holder

 

The Centrasette P Holder has a polypropylene center manifold and end plate,for use when product contact with metal is not desirable or prohibited by your application; for example when processing certain metal sensitive enzymes or oligonucleotides.The manifold and end plate are housed between stainless steel plates to supply the necessary rigidity when operating at higher pressures.Luer fittings on the ¾ in. sanitary polypropylene ports can be used for connection to plastic pressure transducers for monitoring pressures, again without metal contact.The low-cost plastic manifold and end plate can be replaced to avoid cleaning validation or dedicated to a specific application along with a set of cassettes to prevent any risk of cross-contamination.The Centrasette P holder like the Centrasette LV holder is intended for use with Centrasette cassettes when total membrane area will be less than 2.5 m² (27 ft²) of screen channel cassettes or 1.5 m² (16 ft²) of suspended screen cassettes. 

Centrasette LV Holder

The Centrasette LV Holder is manufactured using highly polished 316L stainless steel.This holder has ¾ in. sanitary fractional fitting on the feed/retentate and permeate ports which minimizes the hold-up volume.it is ideal for use in systems that use Centrasette cassettes when total membrane area will be less than 2.5 m2 (27 ft2) of screen channel cassettes or 1.5m2 (16 ft2) of suspended screen cassettes.Centrasette 5 and Centrasette 5AT Holders

The Centrasette 5 holder is intended for use in pilot and process scale applications with up to 5 m² (54 ft²) screen channel Centrasette or Centrasette II cassettes or 4 m² (43 ft²) of suspended screen cassettes.The feed/retentate channels have tapered bores engineered to maintain uniform cross flow and pressure drops across the membrane cassettes.Two permeate ports, one near the feed and the other near the retentate, are designed to reduce backpressure on the permeate side of the membrane.This is especially important when operating at high flux rates.Pressure on the permeate side effectively reduces transmembrane pressure and lowers filtrate flux rates.The highly polished 316L stainless steel unit has ports that mate up with 1 in. sanitary connectors.A calibrated torque wrench and socket is supplied with the holder, as it is with other manual torque holders.
 

 

Centrastak Holders

 

Processes developed at bench scale on Centramate and Centrasette cassettes can be scaled up to process volumes in excess of 10,000 L using a Centrastak system.The Centrastak range of cassette holders have been designed for optimal performance in large-scale production environment.The small footprint makes them ideal for use in process skids and manufacturing suites where space is at a premium.Each level in a Centrastak holder can hold up to 10 m² (107 ft²) of Centrasette cassettes on each side of a central manifold or effectively 20 m² (215 ft²⁾ per level.A single center-manifold significantly reduces hold-up volumes.Feed flow direction is from bottom to top allowing air to be easily expelled from the system.

All Centrastak holders are available in auto-torque format with a hydraulic system,including stainless steel pistons and pump, Centramate for maintaining optimal and uniform compression on the installed cassettes.A pressurized air supply is required to operate the hydraulic pump (60 psi minimum, 125 psi maximum).All wetted surfaces are electropolished, 316L stainless steel.Holder is supplied with surface and weld certification to support I/Q validation. 

 

Maximate Holders

Maximate holders are designed for use with Maximate membrane cassettes.The 316L stainless steel holder has ¾ in. sanitary feed/retentate ports and ½ in. permeate ports.Up to 6 screen channel cassettes (4 suspended screen channel cassettes), 0.19m² (2ft²) will fit into the holder accommodating process fluid volumes from a few hundred milliliters up to over a hundred liters.

Maximate cassettes are chosen for scale-up studies when process-scale volumes will be processed using a Maxisette system that has the same feed/retentate channel path length.

Maxisette Holders

The Maxisette holder has been designed for optimal performance in a large-scale production environment.The longer path length of a Maxisette cassette compared with a Centrasette cassette allows a 40 % reduction in cross flow rate (retentate flow rate), therefore requiring a smaller pump with a corresponding reduction in heating, energy costs and space requirements.The small footprint makes it ideal for use in process skids and manufacturing suites where space is at a premium.

Feed flow direction is from bottom to top allowing air to be easily expelled from the system.Port design in the Maxisette cassette results in a significant reduction in pressure drops and a more uniform pressure profile at operating cross flow rates compared to other cassette formats.This results in higher performance during production and more efficient cleaning.

Processes developed at bench scale on Maximate cassettes can be efficiently scaled up to process volumes in excess of 10,000 L. Maxisette holders are available in auto-torque format with a hydraulic system, including six pistons and a pump, for maintaining optimal and uniform compression on the installed cassettes.A pressurized air supply is required to operate the hydraulic pump (60 psi [4.1 bar] minimum, 125 psi [8.6 bar] maximum).All wetted surfaces are electropolished, 316L stainless steel.All Maxisette Holders are supplied with surface and weld certification.

Technical Specifications

Centramate Cassette Holders

Cassette Holder	Centramate LV Holder	Centramate PE Holder	Centramate Holder
Feed and retentate ports	Female luer SS	¼ in.NPT Fitting (female)	½ in. sanitary, 9.6 mm (0.38 in.) bore
Filtrate ports	Female luer SS	¼ in.NPT Fitting (female)	½ in. sanitary, 8.1 mm (0.32 in.) bore
Maximum membrane area Screen 悬浮筛网	- 0.04 m2 (0.4 ft2) 0.02 平方米（0.2 ft2）	- 0.37 m2 (4 ft2) 0.28 m2 (3 ft2)	- 0.46 m2 (5 ft2) 0.37 m2 (4 ft2)
Nominal dimensions (Width x Length x Depth)	12 x 23 6.6 cm (4½  x 9 x  2½  in.)	9.4 x 24 x 19 cm (3¾ x 9¼ x 7½ in.)	13 x 23 x 16 cm (5¼ x 9 x 6¼ in.)
重量	4 kg (8.75 lbs)	8.6 kg (19  lbs)	6.4 kg (14 lbs)
Maximum operating temperature(2)	50 °C	80 °C	80 °C
Maximum operating pressure	5 bar (75 psi)	6 bar (90 psi)	6 bar (90 psi)

 

Centrasette Cassette Holders

Cassette Holder	Centrasette LV Holder	Centrasette P Holder	Centrasette 5*,  5AT* Holder
Feed and retentate ports	¾ in. sanitary SS	¾ in. sanitary PP	1 in. sanitary SS
Filtrate port	¾ in. sanitary SS	¾ in. sanitary PP	1 in. sanitary SS
Maximum membrane area(1) Screen 悬浮筛网	- 2.0  m2 (22  ft2) 1.5  m2 (16  ft2)	- 2.0  m2 (22  ft2) 1.5  m2 (16  ft2)	- 5  m2 (54  ft2) 4  m2 (43  ft2)
Nominal dimensions (Width x Length x Depth)	26 x 25 x 21 cm (10¼  x 10 x  8½  in.)	30 x 20 x 34 cm (12 x 8 x 13½ in.)	26 x 25 x 27 cm (10¼ x 10 x 10¾ in.)
重量	28 kg (62 lbs)	25 kg (55 lbs)	30 kg (66 lbs)
Maximum operating temperature(2)	80 °C	50 °C	80 °C
Maximum operating pressure	6  bar (90 psi)	5 bar (75 psi)	6  bar (90 psi)

*Extended tie rods available to increase membrane capacity to 5 m2 (54 ft2) for suspended screen channel cassettes.

 

 

Centrastak Cassette Holders

Cassette Holder	Centrastak 100 Holder	Centrastak 200 Holder	Centrastak 300 Holder	Centrastak 400 Holder
Feed and retentate ports	2 in. .sanitary	2 in. .sanitary	2 in. .sanitary	2 in. .sanitary
Filtrate port	1 in. sanitary	1 in. sanitary	1 in. sanitary	1 in. sanitary
Maximum membrane area(1) Screen 悬浮筛网	- 20  m2 (216  ft2) 15  m2 (161  ft2)	- 40  m2 (430  ft2) 30  m2 (323  ft2)	- 60  m2 (645  ft2) 45  m2 (484  ft2)	- 80  m2 (860  ft2) 60  m2 (645  ft2)
Nominal dimensions (Width x Length x Depth)	39 x 91 x 59 cm (15½ x 36 x 23¼ in.)	39 x 91 x 59 cm (15½ x 36 x 37½ in.)	39 x 91 x 107 cm (15½ x 36 x 42 in.)	39 x 91 x 120 cm (15½  x 36 x 47½ in.)
重量	155 kg (340 lbs)	255 kg (560 lbs)	314 kg (690 lbs)	409 kg (900 lbs)
Maximum operating temperature(2,3)	80 °C	80 °C	80 °C	80 °C
Maximum operating pressure	6  bar (90 psi)	6  bar (90 psi)	6  bar (90 psi)	6  bar (90 psi)

1. Cassette blocks (2 m2 (21.6 ft2) or 2.5 m2 (26.9 ft2) are recommended.If 0.5 m2 (5.3 ft2) cassettes are used, stabilizer plates must be used between every 5 cassettes (fine/medium screen) or 3 cassettes suspended screen.

2. Maximum operating temperature may be restricted by cassette operating temperature limit.

3. Holder may be steamed with compatible cassettes, or without cassettes at up to 142 °C.

 

Maximate and Maxisette Cassette Holders

Cassette Holder	Maximate Holder	Maxisette 25 Holder	Maxisette 50 Holder	Maxisette 100 Holder
Feed and retentate ports	¾ in. sanitary	2 in. sanitary	2½ in. sanitary	2½ in. sanitary
Filtrate port	1½ in. sanitary	1½ in. sanitary	1½ in. sanitary	1½ in. sanitary
Maximum membrane area(1) Screen 悬浮筛网	- 1.1  m2 (12  ft2) 0.74  m2 (8  ft2)	- 28  m2 (300  ft2) 28  m2 (300  ft2)	- 56  m2 (600  ft2) 56  m2 (600  ft2)	- 89  m2 (960  ft2) 56  m2 (600  ft2)
Nominal dimensions (Width x Length x Depth)	16 x 44 x 22 cm (6¼ x 17½ x 8¾ in.)	47 x 105 x 57 cm (18½ x 41½ x 22½ in.)	47 x 105 x 97 cm (18½  x 41½  x 38 in.)	47 x 105 x 117 cm (18½  x 41½  x 46 in.)
重量	13.3 kg (29.2 lbs)	455 kg (1000 lbs)	566 kg (1245 lbs)	566 kg (1245 lbs)
Maximum operating temperature(2,3)	80 °C	80 °C	80 °C	80 °C
Maximum operating pressure	6  bar (87 psi)	6  bar (87 psi)	6  bar (87 psi)	6  bar (87 psi)

1. Cassette blocks (2 m2 (21.6 ft2) or 2.5 m2 (26.9 ft2) are recommended.If 0.5 m2 (5.3 ft2) cassettes are used, stabilizer plates must be used between every 5 cassettes (fine/medium screen) or 3 cassettes suspended screen.

2. Maximum operating temperature may be restricted by cassette operating temperature limit.

3. Holder may be steamed with compatible cassettes, or without cassettes at up to 142 °C.

 

Materials of Construction for Wetted Parts

Holder	Centramate PE	Centramate LV	Centramate/Maximate	Centrasette P	Centrasette Maxisette
GeneDisc板	UHMW polyethylene	316L stainless steel	316L stainless steel	聚丙烯	316L stainless steel
Flow distribution 歧管	UHMW polyethylene	316L stainless steel	316L stainless steel	聚丙烯	316L stainless steel
Other components		EPDM o-ring on SS threaded luer connector		EPDM sanitary gaskets

View additional Tangential Flow Filtration Systems and Components.

订购须知

The following table lists individual cassette holders as well as holders sold in combination with fittings packages.Additional combinations and a variety of other accessories are available.

 

描述	Part Number
Centramate PE Holder, including torque wrench and socket	FS002K10
Centramate PE Holder, including fittings package with 3 pressure gauges	FS013K10
Centramate LV Holder, including torque wrench and socket	CM018LV
Centramate SS Holder, including torque wrench and socket	FS001K10
Centramate SS Holder, including torque wrench, fittings package with 3 pressure gauges, 2 diaphragm valves	FS011K10
Centrasette 5 manual torque, including torque wrench and socket	FS001K05
Centrasette P Holder, including torque wrench and socket	FS039K05
Centrasette LV Holder, including torque wrench and socket	FS044K05
Centrasette LV Holder, including torque wrench and socket, fittings package with 3 pressure gauges, 2 diaphragm valves	FS046K05
Centrasette 5 Holder, including torque wrench and socket	FS001K05
Centrasette 5 Holder, including torque wrench and socket, fittings package with 3 pressure gauges, 2 diaphragm valves	FS014K05
Centrasette 5AT Holder	FS020K05
Centrasette 5AT Holder, including torque wrench and socket, fittings package with 3 pressure gauges, 2 diaphragm valves	FS022K05
Centrastak 100 AT Holder	FS050K05
Centrastak 200 AT Holder	FS034K05
Centrastak 300 AT Holder	FS036K05
Centrastak 400 AT Holder	FS038K05
Maximate Holder, including torque wrench and socket	FS001G01
Maximate Holder, including torque wrench and socket, fittings package with 3 pressure gauges, 2 diaphragm valves	FS003G01
Maxisette 25 AT Holder	FS009K50
Maxisette 50 AT Holder	FS013K50
Maxisette 100 AT Holder	FS016K50

 

View additional Tangential Flow Filtration Systems and Components.

pall,颇尔,切向流过滤膜包夹具