颇尔’s Fluorodyne EX grade EDT filter is a 0.1 micron rated, validated, highly retentive mycoplasma control filter to be used where the sterility assurance and economical filtration of culture media or other hard-to-filter fluids is paramount.
A unique three-layer construction contributes to outstanding throughput, high flow rates and the superior retention of bacteria and mycoplasma during the filtration of process fluids.
The Mini Kleenpak™ capsules are compact filters used in the laboratory for volumes of 2 L to 50 L in process development, and in pilot and manufacturing scale operations if processing requirements do not demand a large filter.These filters are the smallest capsule filters in the UpscaleSM Program range to utilize a pleated membrane, and are excellent for modeling filter performance at large production scale.
Key Features and Benefits
- Encapsulated format for higher flexibility, minimized cleaning and low installation costs
- Minimal hold up volume
- Ideal for upscale trials
- Asymmetric built-in prefilter for highest dirt-holding capacity
- High flow rate
- Low protein and preservative binding
- Low extractables
延伸阅读
海报：A. laidlawii Filtration Through a 0.1-micron Rated Filter at Elevated Pressures
Poster: Scale Up of Direct Flow Membrane Filters
文章：Effect of Prefiltration on Scalability of 0.1-µm rated Membrane Filters
文章：A New Direction In Mycoplasma Removal
文章：Bacterial Penetration of 0.2 μm Sterilizing- Grade Filters with a Cholesterol Liposome Carrier:A Comparison of Data
文章：Contamination Costs - Current Trends in Process Economics for Mycoplasma-Retentive Filtration of Cell Culture Media ¹
文章：Evaluating Performance of 0.1 µm Filters for Mammalian Cell Culture Media Filtration ²
文章：Evaluating the Scalability of 0.1 µm-rated Membrane Filters - Part 1 ³
¹ Reproduced with the kind permission of European Biopharmaceutical Review magazine
² ³ External link
材料成分
| Filter Membrane |
Prefilter Layer: Single-layer hydrophilic asymmetric PES Final Filter Layers: Dual-layer hydrophilic PVDF |
| Support/Drainage | 聚丙烯 |
| 囊式过滤器 | 聚丙烯 |
| Filling Bell | 聚碳酸酯 |
| Sealing Technology | Thermal bonding without adhesives |
Operating Parameters ¹
| Maximum Operating Temperature | 40 °C |
| 最大操作压力 | 4.1 bar (60 psi) at 38 °C |
Sterilization Conditions ²
| Autoclavable 'G' option | 3 x 30 minutes at up to 135 °C |
| Gamma Irradiation 'G' option | Maximum of 50 kGy |
• Mini Kleenpak capsules must not be sterilized in-situ by passing steam under pressure
Typical Extractables in Water at 20 °C
| < 5 mg NVR |
Nominal Dimensions
| Maximum Diameter including valves | 68 mm (2.7 in.) |
| Length – Code 2 | 105 mm (4.1 in.) |
| Length – Code 8 | 73 mm (2.9 in.) |
Nominal Effective Filter Area (EFA)
| 200 cm² (0.22 ft²) |
Removal Rating ³
| 0.1 μm sterilizing grade |
Typical Liquid Flow Rates
| 项目 | Part Number* |
|
Mini Kleenpak™ Capsule with Fluorodyne® EX EDT Membrane ¼ in - ½ in (6 mm - 13 mm) hosebarb, supplied non sterile, gamma irradiatable/autoclavable |
KA02EDTP2G |
|
Mini Kleenpak™ Capsule with Fluorodyne® EX EDT Membrane ¼ in - ½ in (6 mm - 13 mm) hosebarb, supplied pre-sterilized using gamma irradiation |
KA02EDTP2S¹ |
|
Mini Kleenpak™ Capsule with Fluorodyne® EX EDT Membrane ½ in - ¾ in (13 mm - 19 mm) sanitary flange, supplied non sterile, gamma irradiatable/autoclavable |
KA02EDTP8G |
|
Mini Kleenpak™ Capsule with Fluorodyne® EX EDT Membrane ½ in - ¾ in (13 mm - 19 mm) sanitary flange, supplied pre-sterilized using gamma irradiation |
KA02EDTP8S¹ |
¹ ‘S’ option with Code 2 connection is provided with filling bell on outlet.It is removable for in-line use
